The effect of ultraviolet radiation on the pathogenesis of Candida albicans in mice

Thesis/Dissertation · Tue Jan 01 04:00:00 EST 1991

OSTI ID:6913497

Denkins, Y M

This dissertation addresses questions concerning the effects of UV radiation on the pathogenesis of opportunistic fungal pathogens such as Candida albicans. UV radiation decreased the survival of Candida-infected mice; however, no correlation was found between suppression of the delayed type hypersensitivity (DTH) response and the course of lethal infection. This suggested that DTH was not protective against lethal disease with this organism. UV radiation also changed the persistence of the organism in the internal organs. UV-irradiated, infected animals had increased numbers of Candida in their kidneys compared to non-irradiated mice. Sensitization prior to UV irradiation aided clearance of the organism from the kidneys of UV-irradiated mice. These data show that UV radiation suppresses cell-mediated immunity to Candida albicans in mice and increases mortality of Candida-infected mice. Moreover, the data suggest that an increase in environmental UV radiation could increase the severity of pathogenic infections.

• Research Organization: Texas Univ., Houston, TX (United States)
• OSTI ID: 6913497
• Country of Publication: United States
• Language: English

Related Subjects

560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CANDIDA
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EUMYCOTA
EXPERIMENTAL DATA
FUNGI
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
INFECTIVITY
INFORMATION
MAMMALS
MICE
MICROORGANISMS
MORTALITY
NUMERICAL DATA
PATHOGENESIS
PLANTS
RADIATION EFFECTS
RADIATIONS
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES
YEASTS