The role of non-standard translation in Candida albicans pathogenesis

Bezerra, Ana Rita; Oliveira, Carla; Correia, Inês; Guimarães, Ana Rita; Sousa, Gonçalo; Carvalho, Maria João; Moura, Gabriela; Santos, Manuel A. S.

doi:10.1093/femsyr/foab032

The role of non-standard translation in Candida albicans pathogenesis

Journal Article · Sat May 22 00:00:00 EDT 2021 · FEMS Yeast Research

DOI:https://doi.org/10.1093/femsyr/foab032· OSTI ID:1786369

; Oliveira, Carla; Correia, Inês; Guimarães, Ana Rita; Sousa, Gonçalo; Carvalho, Maria João; Moura, Gabriela; Santos, Manuel A. S.

ABSTRACT

Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits.

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Sponsoring Organization:: USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain

OSTI ID:: 1786369

Journal Information:: FEMS Yeast Research, Journal Name: FEMS Yeast Research Journal Issue: 4 Vol. 21; ISSN 1567-1364

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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