Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Journal of Bacteriology; (USA)

OSTI ID:6794925

Klig, L S; Friedli, L; Schmid, E ^[1]

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1. GLAXO Institute for Molecular Biology S.A., Geneva (Switzerland)

Phospholipid metabolism in the pathogenic fungus Candida albicans was examined. The phospholipid biosynthetic pathways of C. albicans were elucidated and were shown to be similar to those of Saccharomyces cerevisiae. However, marked differences were seen between these two fungi in the regulation of the pathways in response to exogenously provided precursors inositol and choline. In S. cerevisiae, the biosynthesis of phosphatidylcholine via methylation of phosphatidylethanolamine appears to be regulated in response to inositol and choline; provision of choline alone does not repress the activity of this pathway. The same pathway in C. albicans responds to the exogenous provision of choline. Possible explanations for the observed differences in regulation are discussed.

• OSTI ID: 6794925
• Journal Information: Journal of Bacteriology; (USA), Journal Name: Journal of Bacteriology; (USA) Vol. 172:8; ISSN JOBAA; ISSN 0021-9193
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
CANDIDA
CARBOHYDRATES
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
ESTERS
EUMYCOTA
FUNGI
HOMEOSTASIS
INOSITOL
INOSITOLS
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
LIPIDS
METHYLATION
MICROORGANISMS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
PLANTS
PRECURSOR
SACCHARIDES
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SYNTHESIS
TRACER TECHNIQUES
YEASTS