STUDIES OF THE METABOLISM OF RADIOACTIVE STRONTIUM Sr$sup 89$$,$$sup 90$. I. STUDIES ON THE EFFECTS OF AGE, DIET, AND VARIOUS CHEMICAL AGENTS UPON THE DISTRIBUTION OF Sr$sup 89$$,$$sup 90$ IN ANIMALS
Studies were made on the effects of age, diet, EDTA, sodium citrate, zirconium citrate, calcium chioride, BAL, and parathyroid hormone upon the tissue distribution of Sr/sup 89/ and Sr/sup 90/. In 40-day-old and 3- and 7-month-old male rats kept on a high or low Ca diet, an increase in excretion and decrease in retention of Sr were favored by increasing age and high-Ca diet. The increase in the amount of Sr excretion was due chiefiy to urinary excretion. When EDTA, sodium citrate, and zirconium citrate were administered simultaneously with Sr, there was a statistically significant increase in the urinary excretion of Sr. On the other hand, calcium chloride, BAL, and parathyroid hormone had no effect on Sr metabolism. When EDTA, sodium citrate, and zircorium citrate were administered 4 days after the injection of Sr, an increase in the urinary excretion of the radioisotopes was observed during 24 hr following the injection of the isotopes. The augmentation of excretion caused by zirconium citrate was marked. The results show that elimination of Sr/sup 89/ and Sr/sup 90/ by various agents is greatiy facilitated by early treatment, before the isotopes are incorporated in bone mineral. (P.C.H.)
- Research Organization:
- Kyoto Univ.
- NSA Number:
- NSA-17-012107
- OSTI ID:
- 4704235
- Journal Information:
- Acta Schol. Med. Univ. Kioto, Journal Name: Acta Schol. Med. Univ. Kioto Vol. Vol: 37
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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