STUDIES ON THE METABOLISM OF RADIOACTIVE STRONTIUM (Sr$sup 89$$,$$sup 90$). II. INFLUENCE OF VARIOUS CHEMICAL AGENTS UPON THE DISTRIBUTION OF Sr$sup 89$$,$$sup 90$ IN ANIMALS
The influence of various chemical agents upon the distribution in the body and the daily excretion of subcutaineously injected Sr/sup 8//sup 9//sup ,// sup 9//sup 0/ was examined in male rats weighing 135 to 150 g. EDTA /sub 4/Na, EDTA Ca, sodium citrate, zirconium citrate, calcium chloride, BAL, and parathyroid hormone (kakerbin) were administered, either simultaneously with the radioelements, or 4 days after the injection of radioisotopes. When EDTA /sub 4/ Na, EDTA Ca, sodium citrate, and zirconium citrate were administered simultaineously with Sr/sup 8//sup 9//sup ,//sup 9//sup 0/ there was a statistically significan t increase in urinary excretion of radioactivity, that is, a decrease of Sr/sup 8//sup 9//sup ,//sup 9//sup 0/ deposits in the skeleton. On the other hand, calcium chloride, BAL, and kakerbin had no effect on strontium metabolism. When EDTA /sub 4/Na, EDTA Ca, sodium citrate, and zirconium citrate were administered 4 days after injection of radioisotopes, an increase in the urinary excretion of the radioisotopes was observed. Zirconium citrate caused the greatest increase in excretion. (Abstr. Japan. Med., 1: No. 1, 1960)
- Research Organization:
- Kyoto Univ.
- NSA Number:
- NSA-15-021943
- OSTI ID:
- 4072113
- Journal Information:
- Naika Hokan (Japan), Journal Name: Naika Hokan (Japan) Vol. Vol: 6: No. 2; ISSN NAHOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
STUDIES ON THE METABOLISM OF RADIOACTIVE STRONTIUM (Sr$sup 89$,$sup 90$). III. STUDIES ON THE BINDING OF Sr$sup 89$ AND BONE TISSUE IN VITRO
STUDIES ON THE METABOLISM OF RADIOACTIVE STRONTIUM Sr$sup 89$,$sup 90$. II. STUDIES ON THE BINDING POTENCY OF Sr$sup 89$ TO BONE TISSUE IN VITRO