THE PREVENTION OF RADIATION DEPOLYMERIZATION OF DNA FROM RAT LIVER BY MEANS OF PROPYLGALLATE AND 5-METHOXYTRYPTAMINE

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4694984

Isupova, L S; Balabukha, V S

White rats were given an x-ray dose of 650 r. Propylgallate, which is a free radical inhibitor, and 5-methoxytryptamine, which prevents the oxidative deamination of a bio-substrate, were injected into the rats 15 minutes before the irradiation. The rats were killed 6, 24, and 72 hours after irradiation, and a preparation of DNA was isolated from the liver for viscosity measurements on a 0.2% aqueous solution of DNA. The results show that the injection of propylgallate prevents the radiation depolymerization of DNA for a period of 72 hours after the irradiation. The injection of 5-methoxytryptamine is less effective, since a drop in the viscosity of the DNA solution is observed 24 hours after the irradiation. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030364
• OSTI ID: 4694984
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINES
BIOLOGY AND MEDICINE
CHEMICAL REACTIONS
DNA
EFFICIENCY
FREE RADICALS
LIVER
MEASURED VALUES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OXIDATION
POLYMERIZATION
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RATS
SOLUTIONS
TRYPTAMINES
VARIATIONS
VISCOSITY
WATER
X RADIATION