INVESTIGATION OF A BIOLOGICAL RADIATION PROTECTION. PART II. THE EFFECTS OF CHEMICAL RADIATION-PROTECTION MATERIAL FOR IN VITRO IRRADIATION OF CATTLE SERUM ALBUMIN SOLUTION

Journal Article · Wed May 01 04:00:00 EDT 1963 · Strahlentherapie (West Germany)

OSTI ID:4694888

Koch, R; Staehler, F

In vitro investigations concerning radiation protection were done with 1% solutions of bovine serum albumin using a dose between 1 and 6 million r. Using the ultracentrifugal pattern the percentage of unchanged albumin showed the protective effect. Sulfur-containing substances investigated were: cysteine, thioglycol, thiourea, thiomalonic acid, BAL-sodiumsulfonate, 5- mercaptopyridoxine, and 5mercaptomethylpyridine. Aromatic substances investigated were: adrenaline, tyramine, histamine, nicotinamide, Nabenzoate, synkayvite, serotonin, tryptamine, and tryptophan. All substances show a radiation protective effect. It was obvious, that 15 to 23 moles are necessary to protect l mole of albumin, independent of the chemical structure. The problems of the hydrogen transfer as a protection mechanism and the importance of the SS- and SR-groups in the albumin molecule are discussed. (auth)

• Research Organization: Universitat, Freiburg i. B.
• NSA Number: NSA-17-028757
• OSTI ID: 4694888
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 121; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ADRENALINE
ALBUMINS
AMINES
AMINO ACIDS
BENZOIC ACID
BIOLOGY AND MEDICINE
BLOOD SERUM
CATTLE
CENTRIFUGATION
CHEMICAL REACTIONS
FREE RADICALS
HISTAMINE
HORMONES
HYDROGEN
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIATION PROTECTION
SEROTONIN
SODIUM COMPOUNDS
SOLUTIONS
SYNKAVITE
TRYPTAMINES
TRYPTOPHAN
TYRAMINE
VITAMIN PP
VITAMINS