EFFECTS OF CERTAIN RADIO-PROTECTIVE AGENTS ON THE RADIOSENSITIVITY AND THE LEVEL OF OXYGEN IN ANIMAL TISSUES (in Russian)
Test data on the oxygen level in liver and spleen tissues of 18 to 20 g white rats injected with 0.02 mg of adrenaline, 0.6 mg of acetylcholine, 1.5 mg of tryptamine, 0.5 mg of serotonin, 0.8 mg of phenethylamine, 45 mg of thiourea, and 3 mg of aminoethylisothiouron (AET) indicated that acetylcholine reduces oxygen intensity in the spleen and liver, while the other chemicals produce hypoxia. Combined applications of acetylcholine with amines reduces the oxygen intensity amplified by the amine. Combined acetylcholine and adrenaline or tryptamine and serotonin induces a strong hypoxia (60 to 70%) and results in the survival of 35 to 70% of rats exposed to lethal doses, while applications of adrenaline, phenethylamine, and tryptamine induced less pronounced hypoxia (15 to 30%) with only 5 to 20% survival. Tiourea does not affect the oxygen level in the spleen but induces a slowly rising hypoxia in the liver. (R.V.J.)
- Research Organization:
- Inst. of Experimental Pathology and Therapy, Academy of Sciences, USSR
- NSA Number:
- NSA-17-002892
- OSTI ID:
- 4763874
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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