EFFECT OF RADIOACTIVE PHOSPHORUS ON MINERAL AND PROTEIN METABOLISM IN CALCIFYING TISSUES (in Russian)
Radioactive phosphorus was injected intraperitoneally to a strain of inbred rats as Na/sub 2/HP/sup 32/O/sub 4/ in physiological in saline solution in doses of 0.5, 1, 2, and 4 mu curies per gram of body weight. Mineral and protein were traced with Ca/sup 45/ (Ca/sup 45/Cl/sub 2/) and C/sup 14/ (glycine- C/sup 14/). Radiation damage was determined from the leucocyte and erythrocyte contents of the blood. Animals were sacrificed at from two to ninety days after the P/sup 32/ was given and pathology studies were made on the calcifying tissues and internal organs of some of the animals. Four hundred and sixteen samples were studied, and the data were treated statistically. The nature and degree of the changes depended on the size of the dose of P/sup 32/. In doses of 0.5, 1, and 2 mu curies/g, P/sup 32/ increased the mineral and protein metabolic processes in calcifying tissue for the first twenty days after its administration and then decreased it. With a dose of 4 mu curies/g, the metabolic processes decreased after two days; the level of Ca/sup 45/ and C/sup 14/-labeled glycine decreased in comparison with those in the controls. The greatest change in the bones and the least in the teeth, and the change in protein metabolism was greater than that in the mineral. The changes are similar to those caused by external irradiation with x rays but are more stable. The changes precede the development of morphological changes in the tissues. Detailed tables of data and 28 references are given. (TTT)
- Research Organization:
- Medical Stomatological Inst., Moscow
- NSA Number:
- NSA-17-031925
- OSTI ID:
- 4694723
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Vol. Vol: 3; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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AMINO ACIDS
BIBLIOGRAPHY
BONES
CALCIUM 45
CALCIUM CHLORIDES
CARBON 14
ERYTHROCYTES
GLYCINE
LABELLED COMPOUNDS
LEUCOCYTES
METABOLISM
PHOSPHORUS 32
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SODIUM CHLORIDES
SODIUM PHOSPHATES
SOLUTIONS
STABILITY
STATISTICS
TABLES
TEETH
TISSUES
VARIATIONS
X RADIATION