EFFECTS OF INCORPORATED RADIOACTIVE IODINE ON PROTOMETABOLISM IN CALCIFIED TISSUES

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4023516

Prokhonchukov, A A

Four sets of experimerts were carried out with 156 inbred rats weighing 132.4 plus or minus 3.6 g treated with a single dose of /sup 131/I injected as carrier-free potassium iodide in doses of 0.5, 1, 2, and 4 mu C/g animal weight. Glycine, labeled with /sup 14/C in the methyl group, was used for determining protometabolism in 636 specimens of calcified protein tissue obtained from irradiated rats that were put to death from 1 to 120 days following the exposure. It was found that a 0.5- mu C dose of /sup 131/I injected into rats induced a hypothyrosis, a 1 mu C/g dose induced a strong hypothyrosis, while 2 to 4 mu C resulted in destruction of the thyroid gland. A weak resorption of jaw bone tissue was observed soon after the injection of 4- mu C/g doses. Fibrosclerosis of the jaw bone tissue was developed at later dates while neither teeth nor hip bone showed any effects. It was also found that the glycine metabolism disturbance is a direct function of the /sup 131/I dose. (R.V.J.)

• Research Organization: Moscow Central Research Inst. of Stomatology
• NSA Number: NSA-18-019679
• OSTI ID: 4023516
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
BONES
CALCIUM
CARBON 14
DISEASES
GLYCINE
IODINE 131
LABELLED COMPOUNDS
METABOLISM
METHYL RADICALS
PERFORMANCE
POTASSIUM IODIDES
PROTEINS
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RADIOACTIVITY
RATS
TEETH
TESTING
THYROID
TISSUES
TRACER TECHNIQUES
VARIATIONS