CHANGES IN THE METHIONINE-CARBON-14 METABOLISM IN CALCIFIED TISSUES DURING ACUTE RADIATION SICKNESS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4768359

Prokhonuchkov, A A

Injury to the mineral metabolism is one of the most important pathogenic factors in the development of radiation lnjury; in particular it is also established that the metabolism of C/sup 14/-labeled glycine is also disturbed, (Radiobiologiya 1: 340(1961)). This work was extended to include the metabolism of C/sup 14/-labeled methionine under the same experimental conditions, using inbred rats exposed to a single, whole-body radiation of 50 r. The animals were killed 1 to 50 days after the exposure. It was found that within 1 to 30 days the methionine metabolism is strongly depressed. The thighs and to a lesser extent the teeth of the irradiated animals exhibited the most marked reduction in the incorporation rate of methionine. After 50 days the methionine content of the exposed animals approached that of the control group; this normalization of the metabolism coincided with the initial stages of the regenerative processes in the calcified tissues. It was concluded that the calcified tissues are not as radiosensitive as it was assumed previously. (TTT)

• Research Organization: Medico-Stomatological Inst., Moscow
• NSA Number: NSA-16-032860
• OSTI ID: 4768359
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
BODY
CALCIUM COMPOUNDS
CARBON 14
GLYCINE
LABELLED COMPOUNDS
METABOLISM
METHIONINE
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY
RATS
REGENERATION
TISSUES