TREATMENT OF RADIATION SICKNESS COMPLICATED BY ACUTE BLOOD LOSS
ABS>An investigation was conducted of the effect of combined treatment with plasma substitutes, vitamin B/sub 6/, and chlortetracycline in animals subjected to x-irradiation and acute hemorrhage. Twenty four rabbits were irradiated with a dose of 800 r, and eight dogs with a dose of 700 r. The animals were then bled from the femoral artery so as to bring about a blood loss to the extent of 40 to 60% of the total blood volume. Immediately afterwards the plasma substitutes polyglucin and ArmIPK were injected intravenously in a volume equal to that of the blood removed. Chlortetracycline was given in the food in a dose of 25,000 units (rabbits) or 100,000 units (dogs) twice daily for 2 to 3 weeks. Vitamin B/sub 6/ was given in a dose of 0.2 ml of 1% solution until the red blood count returned to normal. The plasma substitutes were effective in reversing shock, and 17 rabbits and 6 dogs survived the acute effects of the blood loss. Twelve rabbits and 1 dog survived the subsequently developing acute radiation sickness for a period of 3 months or longer. Six female rabbits which survived were mated, and 2 subsequently became pregnant and gave birth to normal litters. (OTS)
- Research Organization:
- Radiobiological Section, Academy of Sciences, Armenain SSR
- NSA Number:
- NSA-17-030448
- OSTI ID:
- 4693620
- Journal Information:
- Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr., Journal Name: Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr. Vol. Vol: 1
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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