THE EFFICACY OF BLOOD SUBSTITUTION WITH POLYGLUCINE IN EXPERIMENTAL TREATMENT OF RADIATION SICKNESS (in Russian)
The therapeutic effect was studied of two blood substitutions with polyglucine (10 to 11% of the total quantity of blood) on the first and third day following irradiation against the background of various therapeutic substances (antibiotics, antihemorrhagic and antihistaminic preparations, hemotransfusions). The experiments were staged on 21 dogs subjected to X-ray irradiation (600 r). The indices of effectiveness were the following. the survival of dogs, clinical symptomatology, and changes of the peripheral blood and autopsy data. In a number of animals the coagulation time, the permeability and resistance of skin capillaries, as well as the general content of protein in the blood serum was studied. As was established, the above variant of therapy considerably increased the survival of irradiated animals (of the 11 dogs under treatment 9 survived, of the 10 control dogs only 2 survived), alleviated the clinical course of acute radiation sickness, and favorably influenced the laboratory indices of hemorrhagic diathesis (blood coagulation, permeability, and resistance of skin capillaries). Additional experiments, staged on 10 dogs, with the exclusion of polyglucine transfusions from the complex of therapeutic measures, decreased by many times the therapeutic effect of treatment (of the 10 treated dogs only 3 survived, of the 7 controls only 2). Polyglucine transfusions considerably increase the efficacy of the complex treatment of acute radiation sickness. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-13-017722
- OSTI ID:
- 4242803
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 7; ISSN MERAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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