COMPLEX TREATMENT OF RADIATION SICKNESS IN BLOOD LOSS

Journal Article · Fri May 01 00:00:00 EDT 1959 · Vestnik Rentgenol. i Radiol.

OSTI ID:4241365

Chaikovskaya, M Ya; Sergel, O S; Elpatevskaya, G N

Development is reported of a combined method of treatment of radiation sickness complicated by blood loss. Experiments were carried out on dogs, irradiated 500 r. Twenty-four dogs weighing from 14 to 20 kg were under observation (18 experimental and 6 control). Various blood substitutes were used (Belenky's serum, parenterin, L-103 preparation) together with antibodies (biomycin, streptomycin) and vitamins (C, B/sub 12/, P, and folic acid). The combined method of therapy was effective in the treatment of radiation sickness complicated by blood loss. The course of radiation sickness in the treated animals was of a mild and average severity, as judged by the manifestations of clinical symptoms and by the duration of the disease. The morphological changes in the bone marrow and in the peripheral blood, as well as the biochemical changes in the blood serum, were of average severity and of short duration. Seventeen of the treated 18 animals survived. Only 2 of the 6 control animals remained alive. Blood substitutes made of heterogenic blood should find widespread use in the treatment of radiation sickness complicated by blood loss. Parenterin and L-103 preparation were the most effective in the treatment of radiation sickness in our experiments. Belenky's serum gave the worst results. Folic acid coupled with vitamin B/sub 12/ promoted and accelerated the regeneration of the red blood cells in the irradiated animals. Leukogen gives a good effect in the treatment of leukopenia resulting from irradiation. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-13-016732
• OSTI ID: 4241365
• Journal Information: Vestnik Rentgenol. i Radiol., Journal Name: Vestnik Rentgenol. i Radiol. Vol. Vol: 34, No. 3
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANTIBIOTICS-- BIOMYCIN-- BLOOD SUBSTITUTES-- HEMORRHAGE-- RADIATION DOSES-- STREPTOMYCIN-- TRANSPLANTS-- WEIGHT
BIOCHEMISTRY-- BLOOD-- BLOOD SERUM-- BLOOD SUBSTITUTES-- BONE MARROW-- FOLIC ACID-- HEMORRHAGE-- SURVIVAL TIME-- VITAMIN B GROUP-- VITAMIN B-12-- VITAMIN C-- VITAMIN P-- VITAMINS
BIOLOGY AND MEDICINE
BLOOD SUBSTITUTES-- DRUGS-- ERYTHROCYTES-- FOLIC ACID-- LEUCOCYTES-- LEUKOGEN-- QUANTITY RATIO-- RADIATION EFFECTS-- REGENERATION-- VARIATIONS-- VITAMIN B GROUP-- VITAMIN B-12-- VITAMINS
DOGS-- EFFICIENCY-- MEDICINE-- RADIATION SICKNESS-- THERAPY