TREATMENT OF RADIATION SICKNESS COMPLICATED BY LOSS OF BLOOD (in Russian)
Removal of 400 to 600 ml of blood before the irradiation of dogs (14 to 20 kg weight) with a dose of 500 r resulted in a rather light form of radiation sickness. The leukopenia with a minimum leukocyte count of 4000 per mm/sup 3/ on the l8th to 2Oth day lasted only a short time. Removal of 100 to 600 ml of blood 12 hr after irradiation resulted in death in the majority of cases on the l4th to l6th day sfter irradiation with a complete disappearance of reticulocytes on the 5th day. Removal of 250 to 300 ml of blood 12 hr after irradiation with replacement by donor blood and the application of antibiotics and vitamin B/sub 12/ resulted in a light form of radiation sickness. A control group which did not receive any donor blood or antibiotics suffered from a more severe form of radiation sickness. The reticulocyts count in the peripheral blood of the treated dogs was observable during the course of the whole experiment and exceeded the initial figure on the 26th day. I the control group the reticulocytes appeared only on the 4lst day after irradiation. The leukopenia was mild and lasted only a short time in the treated group of dogs (3300 on the l7th day and 8700 on the 26th day after irradiation), while it wss - more severe and prolonged in the control group (700 to 1000 counts from the 6th to the 27th day sfter irradiation). The use of a protein concentrate had a favorable influence on the hematopoietic function. An enlarged spleen was observed in all the animals treated with serum. antibiotics, and vitamins. Cytological smears of the spleen showed the presence of numerous erythroblasts and pointed to the development of a compensatory hematopoietic function in the spleen. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-15-002553
- OSTI ID:
- 4118072
- Journal Information:
- Trudy Vsesoyuz. Konf. Med. Radiol., Journal Name: Trudy Vsesoyuz. Konf. Med. Radiol.
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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