THE ANTIBODY-FORMING FUNCTION OF THE BODY IN RELATION TO THE ROUTES OF INJECTION OF THE ANTIGEN AND THE TIMING OF THE ACTION OF IONIZING RADIATION
Rabbits were injected with an antigen intravenously, subcutaneously or intradermally, either 4 days before, or 4 days after, x-irradiation of the whole body in a dose of 350 r. The antigen consisted of a heated suspension of salmonella typhimurium containing 10 million organism per ml. Agglutinin titres were determined in samples of blood removed at intervals up to 21 days. Higher titres (256 to 1920) were obtained by intravenous immunization than by the subcutaneous (224 to 1408) or intradermal (192 to 896) routes. Irradiation carried out before immunization inhibited antibody formation, but to a lesser extent with intravenous administration (maximum titre 1280) than with subcutaneous (568) administration; with intradermal administration a rise in titre (2000) was noted on the 10th day, and values higher than normal persisted until death. When immunization preceded irradiation there was no inhibition of the immune response and some stimulation was noted, particularly with intravenous administration. A higher mortality occurred in the groups of rabbits in which irradiation preceded immunization. These two factors, both singly and in combination, led to a fall in the red and white cell counts, haemoglobin content, and prothrombin time. (OTS)
- Research Organization:
- Radiobiological Section, Academy of Sciences, Armenian SSR
- NSA Number:
- NSA-17-030446
- OSTI ID:
- 4685465
- Journal Information:
- Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr., Vol. Vol: 1; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
ANTITOXIN FORMATION BY CELLS TRANSPLANTED TO IRRADIATED ANIMALS
MITOTIC ACTIVITY OF IMMUNOLOGICALLY COMPETENT LYMPHOID CELLS TRANSFERRED INTO X-IRRADIATED RECIPIENTS