EFFECT OF RADIATION ON PURIFIED ENZYMES AND PROTECTIVE ACTION OF SULFANILAMIDE DISULPHIDE (in Italian)
Previous research on the inactivation of pure compounds of lactic dehydrogenase of yeast by means of ultraviolet and roentgen radlations was extended to other purified enzymes extracted from animal tissues; liver alcohol dehydrogenase, heart lactic dehydrogenase, and pancreas ribonuclease. It was possible to confirm that the inhibitory reaction caused by radiation shows a monomolecular trend, using both ultraviolet and roentgen radiation, and that it depends on the free radicals produced in the irradiated solution. The inhibitory effect of ultraviolet radiation is remarkably roduced by the presence of compounds of the type bis (2,2-annino-4,4',sulfainamide)-disulphide at concentration ranging between 10/sup -4/- 10/sup -5/ M. In these conditions it is possible to observe a decrease of the yield of the inactivation reaction. Also the inhibitory effect of roentgen rays is reduced by the disulphide. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-030303
- OSTI ID:
- 4679372
- Journal Information:
- Atti Uffic. Congr. Sci., Sez. Nucl., 1960, Journal Name: Atti Uffic. Congr. Sci., Sez. Nucl., 1960
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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