ACTION OF RADIATION ON ENZYMES
The inhibitory mechanism of radiation on enzymes is discussed from the results of irradiation by gamma rays on crystalline urease, glutamic and alcohol dehydrogenases, and catalase, respectively. Inactivations of the enzymes in aqueous solutions were shown to be indirect actions of the reaction prcducts between water molecules and gamma rays. Protecting reagents against the inactivation were studied; thiol compounds were found to be efficient for the protection of reversible inactivations of sulfhydryl enzymes. Coenzymes of the dehydrogenases, such as diphosphonucleotide, were more radioresistunt than apo- enzymes. A close relation was observed between the inhibitory damage of coenzyme molecules and changes in their ultraviolet absorption. (Absts. Japan. Med., 1: No. 6, 1961)
- Research Organization:
- Kyoto Univ.
- NSA Number:
- NSA-15-023343
- OSTI ID:
- 4035904
- Journal Information:
- Saihokaku Kagakukyokai Simposia, Journal Name: Saihokaku Kagakukyokai Simposia Vol. Vol: 9
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
ACTIONS OF GAMMA RADIATION ON ENZYMES AND ENZYME SYSTEMS
ELECTRON SPIN RESONANCE STUDIES ON THE MECHANISM OF ENZYME INACTIVATION BY DIRECT ACTION OF GAMMA RADIATION