ACTIONS OF GAMMA RADIATION ON ENZYMES AND ENZYME SYSTEMS
The effects of gamma radiation on several enzymes, coenzymes, and multienzyme systems were studied. Conditions which affect the inactivation of enzymes and a coenzyme were studied. The inhibitions of enzyme activities were proved to occur exponentially with dose. G-values of enzyme inactivations depended on the concentration of enzyme solutions. Previously added thiol compounds were found to protect the inactivation of sulfhydryl enzyanes by gamma irradiation. Radiolytic damages to enzymes and coenzymes were investigated quantitatively. Ion exchange chromatography confirmed inorganic phosphate splitting which occurred when diphosphopyridine nucleotide received relatively large gamma doses. A study of the biochemical effects of gamma rays on enzymes proved that some were more radiosensitive than others. (B.O.G.)
- Research Organization:
- Kyoto Univ.
- NSA Number:
- NSA-14-011449
- OSTI ID:
- 4199201
- Journal Information:
- Bull. Inst. Chem. Research, Kyoto Univ., Journal Name: Bull. Inst. Chem. Research, Kyoto Univ. Vol. Vol: 37
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CHROMATOGRAPHY
DECOMPOSITION
ENZYMES
GAMMA RADIATION
HYDROLYSIS
ION EXCHANGE
NUCLEIC ACIDS
ORGANIC SULFUR COMPOUNDS
PHOSPHATES
PYRIDINES
QUANTITY RATIO
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIOLYSIS
RADIOSENSITIVITY
REACTION KINETICS
SOLUTIONS
THIOLS