The Acute Toxic Effects of Cysteamine and Their Modification by X-irradiation
Journal Article
·
· International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
The toxic effects of cysteamine in mice are described. A dose of just over twice the usual radioprotective dose caused severe convulsions and killed about half the injected animals. The dangers of using this compound in man are discussed. When a toxic dose of cysteamine was followed by 100 rads of x rays 2to 15 min later, there was a statistically significant reduction in the number of deaths caused by the cysteamine. Doses of 500 to 5000 rads had no effect on cysteamine mortality. Possible mechanisms are discussed, and a radiation effect on the nervous system is thought to be more likely than a reversal of the protective effect of cysteamine. (auth)
- Research Organization:
- Medical Research Council, Harwell, Berks, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-031898
- OSTI ID:
- 4666334
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 4 Vol. 6; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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