Generating electrospray from microchip devices using electroosmotic pumping

Journal Article · Sat Mar 15 04:00:00 EST 1997 · Analytical Chemistry (Washington)

DOI:https://doi.org/10.1021/ac9610671· OSTI ID:466365

Ramsey, R S; Ramsey, J M ^[1]

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1. Oak Ridge National Lab., TN (United States)

A method of generating electrospray from solutions emerging from small channels etched on planer substrates in described. The fluids are delivered using electroosmotically induced pressures and are sprayed electrostatically from the terminus of a channel by applying an electrical potential of sufficient amplitude to generate the electrospray between the microchip and a conductor spaced from the channel terminus. No major modification of the microchip is required other than to expose a channel opening. The principles that regulate the fluid delivery are described and demonstrated. A spectrum for a test compound, tetrabutylammonium iodide, that was continuously electrophoresed was obtained by coupling the microchip to an ion trap mass spectrometer. 35 refs., 6 figs.

• DOE Contract Number: AC05-96OR22464
• OSTI ID: 466365
• Journal Information: Analytical Chemistry (Washington), Journal Name: Analytical Chemistry (Washington) Journal Issue: 6 Vol. 69; ISSN ANCHAM; ISSN 0003-2700
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
DESIGN
ELECTROPHORESIS
IODIDES
MASS SPECTRA
MEASURING INSTRUMENTS
MICROELECTRONIC CIRCUITS
ORGANIC COMPOUNDS
OSMOSIS
SOLUTIONS