RADIOPROTECTIVE AGENTS. A CORRELATIVE STUDY OF RNA CONTENT AND THE DEGREE OF RADIORESISTANCE OF CELLS IN VITRO
Technical Report
·
OSTI ID:4662378
In vitro studies revealed that a 24-hour preirradiation treatment of an amnion cell line with yeast RNA increased cell survival in proportion to the yeast RNA content in the medium. Conversely, ribonuclease treatment increased radiosensitivity. However, the protective response was observed only after 8 to 10 hours of preirradiation treatment with yeast RNA. Some increase in cell survival was recorded at 4 to 6 hours when an alkaline hydrolysate of yeast RNA was used. Microspectrophotometric measurements of cytoplasmic basophilia revealed substantially increased optical density within 4 hours of incubation with RNA. The delay in a protective response during this period may have been due to the time required for digestion and resynthesis into an active radioprotective agent. A correlation between RNA synthesis and the radioprotective response confirmed this hypothesis. (auth)
- Research Organization:
- Pasadena Foundation for Medical Research, Calif.
- NSA Number:
- NSA-17-027060
- OSTI ID:
- 4662378
- Report Number(s):
- SAM-TDR-63-17
- Country of Publication:
- United States
- Language:
- English
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