RADIOPROTECTIVE AGENTS. ANALYSIS OF THE POTENTIAL ANTIRADIATION EFFECT OF NUCLEIC ACIDS OR THEIR PRECURSORS
A total of nine compounds, including nucleic acids, purines, pyrimidines, and one nucleoside, were tested in vitro for activity as radioprotective agents. One agent which proved to be effective was yeast ribonucleic acid (RNA). Four others, which showed moderate potential, were calf thymus deoxyribonucleic acid (DNA), yeast DNA, orotic acid, and adenine. Guanine, xanthine, uracil, and deoxyadenosine had no protective effect in the test system. Yeast RNA was found to be relatively nontoxic to amnion cells over a 24-hr treatment period, but a chronic exposure of the cells to 0.5 mg/ml for 6 days caused a decrease in the growth rate to about 52% of control cultures. Preirradiation treatment of 7 different cell strains with 0.1 mg/ml yeast RNA resulted in a widely variable protective response. Treated populations of nonmalignant origin showed more cells surviving 700 r gamma radiation than did untreated, irradiated control cultures. Malignant cells, including KB, HeLa, and Detroit 6 strain of bone marrow, showed no protective response. (auth)
- Research Organization:
- Pasadena Foundation for Medical Research, Calif.
- NSA Number:
- NSA-15-022163
- OSTI ID:
- 4044648
- Report Number(s):
- AF-SAM-61-58
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
INTERRELATIONS OF NUCLEIC ACID AND PROTEIN SYNTHESES IN RADIATION INDUCED MUTATION INDUCTION IN BACTERIA
RADIOPROTECTIVE AGENTS. THE EFFECTS OF DEPOLYMERIZED YEAST RIBONUCLEIC ACID ON RADIATED HUMAN CELLS IN TISSUE CULTURE