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INFLUENCE OF WHOLE-BODY X-IRRADIATION ON ASCORBIC ACID CONTENT IN SOME ORGANS AND PERIPHERAL BLOOD OF RATS AND GUINEA PIGS (in Russian)

Journal Article · · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)
OSTI ID:4659908
The effects of radiation on the ascorbic acid (AA) contert in various organs and in the blood of animals synthesizing AA (rats) are compared with effects in animals not synthesizing AA (guinea pigs). For 12 to 14 days prior to, and during the experiment, young male rats and guinea pigs were maintained on scorbutogenic rations. Guinea pigs were additionally given 15 reg of AA daily (elevated dose) each and 2 mg (minimal dose to prevent scurvy). Acute radiation sickness was induced in the animals by a single whole-body 700 r dose of x rays. The concentration of AA in liver, spleen, adrenals, and blood plasma was determined one hr, 24 hrs, 3 days, and 7 days postirradiation. Results of experiments were processed using variational statistics and expressed in percents. As a result of x irradiation, it was found that changes of the AA content occur in a number of vitally important organs and in blood plasma of rats and guinea pigs. The character of these changes is different in animals that synthesize AA and in those that do not, the sharpest differences being found during the first minutes after irradiation in the tissue of the brain and liver. Significant differences in the AA content of various organs in the two species may be explained by the difference in reaction of those organs to the irradiation. Literature on the effects of 550- 1000 r radiation doses on AA content in animals is reviewed. (H.M.G.)
Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-17-037096
OSTI ID:
4659908
Journal Information:
Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

ADRENAL GLANDS
BIBLIOGRAPHY
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD PLASMA
BODY
BRAIN
GUINEA PIGS
LIVER
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RATS
SPLEEN
VARIATIONS
VITAMIN C
VITAMINS
X RADIATION