ASCORBIC ACID AND IRRADIATION. I. THE VARIATIONS OF ASCORBIC ACID AND DEHYDROASCORBIC ACID IN IRRADIATED GUINEA PIGS

Journal Article · Sat Oct 01 04:00:00 EDT 1960 · Radiobiol. latina

OSTI ID:4044796

Billiteri, A; Gasso, G

The behavior of ascorbic and dehydroascorbic acids in the blood or organs of irradiated guinea pigs was studied. In the blood a progressive diminution in vitamin C content was observed. Moreover, this diminution was apparent during the first five hours after irradiation and affected the oxidized form earlier than the reduced form. In the tissues, changes in vitamin C content occur in three phases: at first (1 to 2 hours) there is a sharp fall which is followed by a return to normal or even raised values in certain organs (5 hours to 6 days); finally the content diminishes again (in the adrenals, brain, spleen, gonads after 3 to 8 days). It is the reduced form of ascorbic acid which usually accounts for the variations in the organs; in the spleen, however, the oxidized form increases appreciably. It was observed finally that post-irradiation atrophy of the spleen and gonads is not associated with any diminution in their capacity to fix ascorbic acid, of which the content in mg/g remains constant. (auth)

• Research Organization: Universita, Catania, Italy
• NSA Number: NSA-15-022133
• OSTI ID: 4044796
• Journal Information: Radiobiol. latina, Journal Name: Radiobiol. latina Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
BLOOD
BRAIN
GLANDS
GONADS
GUINEA PIGS
IRRADIATION
QUANTITY RATIO
SPLEEN
TISSUES
VITAMIN C
VITAMINS