ASCORBIC ACID METABOLISM IN THE WALLS OF THE AORTA IN DEVELOPMENT OF RADIATION INJURY

Journal Article · Tue Nov 01 04:00:00 EST 1960 · Biochemistry (U.S.S.R.)(English Translation)

OSTI ID:4094838

Polikarpova, L I

Acute radiation sickness causes changes in ascorbic acid metabolism in aorta walls in animals which synthesize ascerbic acid (rabbits) and in those which do not (guinea pigs). In guinea pigs the content of ascorbic acid decreases 3 to 5 days after irradiation with a sharp increase in the amount of dehydroascorbic acid on the third day; in rabbits the content of ascorbic acid increases on the first day with further fall to normal in relation to the unchanged content of dehydroascorbic acid. The ratio of the amount of dehydroascorbic acid to the amount of ascorbic acid, an indication of the direction of the oxidation-reduction processes in the orgarism, sharply increased in guinea pigs 3 to 5 days after irradiation, and in rabbits was unchanged. In guinea pigs, the development of radiation sickness led to a considerable deficit of ascorbic acid in the aorta walls, and in rabbits this was not found. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-010702
• OSTI ID: 4094838
• Journal Information: Biochemistry (U.S.S.R.)(English Translation), Journal Name: Biochemistry (U.S.S.R.)(English Translation) Vol. Vol: 25
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ASCORBIC ACID
BIOLOGY AND MEDICINE
BLOOD VESSELS
ENZYMES
GUINEA PIGS
METABOLISM
RABBITS
RADIATION INJURIES
RADIATION SICKNESS
VITAMINS