ON THE INFLUENCE OF THIOPHENE-2-CARBONIC ACID N-PHENYLAMIDINE ON THE BONE MARROW CHANGES IN ACUTE RADIATION DISEASE

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Acta Biologica et Medica Germanica (East Germany)

OSTI ID:4657519

Zographov, D G; Baev, I A

Histologic examination of bone marrow was conducted for 30 days in rats exposed to a 650-r, whole-body dose of 180-kv x rays. Some rats were injected 5 min before exposure with 5 mg/kg of thiophene-2-carbonic acid N-phenylamidine compound, dissolved in a 1% solution of acetic acid at pH 5. The total mitotic index of myelocytes reached an earlier (5th day), higher max (14%) in the injected rats than in rats receiving only irradiation (10th day, 10% in comparison with a control index of 5%). This index fell on the lst day in untreated and rose in treated animals. The maturation indices in treated and untreated rats were 1.5 and 2.3 for granulocytes and 14 and 19 for erythroblasts on the 1st day postirradiation; their subsequent changes were similar in the 2 groups. The marrow content of blood cells and their precursors fell to a min on the 5th day in both groups, to 33% of the total cells in the treated rats and 17% in untreated rats. The recovery as reflected in this value was greater in the treated animals. The postirradiation fall was less marked in the treated group with respect to lymphocytes, megakaryocytes, granulocytes, and erythroblasts. It is concluded that this compound protects radiosensitive myelocytes from the initial radiation damage but has no direct action per se on hematopoiesis. (BBB)

• Research Organization: Inst. of Radiobiology, Sofia
• NSA Number: NSA-17-038889
• OSTI ID: 4657519
• Journal Information: Acta Biologica et Medica Germanica (East Germany), Journal Name: Acta Biologica et Medica Germanica (East Germany) Vol. Vol: 8; ISSN ABMGA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ACETIC ACID
ACIDITY
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD FORMATION
BODY
BONE MARROW
LEUCOCYTES
LYMPHOCYTES
MITOSIS
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RATS
RECOVERY
SOLUTIONS
X RADIATION