INELUENCE OF THE N-PHENYLAMIDINE OF THIOPHENE-2-CARBOXYLIC ACID ON THE BONE- MARROW CHANGES IN ACUTE RADIATION SICKNESS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Acta Biologica et Medica Germanica (East Germany)

OSTI ID:4694160

Zografov, D G; Baev, I A

White male rats were irradiated with 650 r, 5 min after administration of 5 mg/100 g of a 1% solution of N-phenylamidine of thiophene-2-carboxylic acid (PTC) in acetic acid. Controls were rats that were either only irradiated, or rats that received only PTC. 1, 3, 5, 10, 15, and 30 days after irradiation the rats were anesthetized and about 1000 cells of bone marrow were removed from their tibias and examined in smear preparations. The mitotic index in PTCprotected animals was significantly higher than in irradiated controls. There were more immature granulocytes and erythroblasts in the protected rats one day after irradiation but there was no difference in lymphocytes or megakaryocytes. The results indicate that radiation damage is smaller and that there is a quicker recovery of all types of cells except lymphocytes in rats protected by PTC. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-021580
• OSTI ID: 4694160
• Journal Information: Acta Biologica et Medica Germanica (East Germany), Journal Name: Acta Biologica et Medica Germanica (East Germany) Vol. Vol: 8; ISSN ABMGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMIDINES
BIOLOGY AND MEDICINE
BONE MARROW
CHEMICALS
HETEROCYCLICS
LYMPHOCYTES
MITOSIS
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENYL RADICALS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
RECOVERY