Comparative Chemical Protection to the Intestinal and Hematopoietic Systems of Whole-Body X-Irradiated Mice

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Radiation Research

DOI:https://doi.org/10.2307/3571468· OSTI ID:4653449

Maisin, Jean R.; Doherty, David G.

Chemical protection by AET, MEA, D-2-ABT, APMT, serotonin, and a combination of AET and serotonin of the alimentary tracts of mice against 900, 1500, 2000, and 2500 r, and the hematopoietic system after 1500 r has been studied. AET and MEA offered the best intestinal protection, AET being superior to MEA at ali dose levels. Doubling the optimal intraperitoneal dose of AET and MEA by oral administration failed to increase the degree of intestinal protection. Finally, combined treatment with AET and serotonin, while providing better protection to the bone marrow than either alone, did not increase intestinal protection beyond that of AET alone.

• Research Organization: Armed Forces Inst. of Pathology, Washington, D.C.; Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-033762
• OSTI ID: 4653449
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 19; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
AMINES
BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
BONE MARROW
CHEMICALS
INTESTINE
MEA
MICE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION PROTECTION
SEROTONIN
X RADIATION