ACTION OF HIGH DOSES OF PARATHORMONE ON THE BEHAVIOR OF STRONTIUM AND CALCIUM IN BONE AND BLOOD SERUM: A CONTRIBUTION TO THE MECHANISM OF ACTION OF PARATHORMONE (in German)
Journal Article
·
· Biochemische Zeitschrift (West Germany) Superseded by Eur. J. Biochem.
OSTI ID:4645585
Rats were fed Sr-containing diets for 23 or 60 days and then with a standard Ca-containing diet for 30 days during which Sr and Ca assays were made in bone and blood. During this 30-day period, some of the rats were injected daily with high doses of parathyroid hormone (1 or 2 USP units per day) to determine the influence of the hormone on elimination of Sr from the skeleton. Samples of compact (tibia + femur) and spongy (vertebra) bone were ashed and analyzed. In both kinds of bone and in both sexes, the hormone caused a delay in removal of Sr from the skeleton. In compact bone Sr content of the ash was about 5% greater 30 days after treatment with 1 unit/day than in the absence of treatment. In spongiosa the difference was approximates 10%. Calcium contents were not significantly affected in either type of bone. In both sexes, hormone treatment increased the Sr and decreased the Ca levels in serum. E.g., 30 days after treatment with 2 units/day the Sr levels were 5.84 and 5.28 mg% in males and females compared to levels of 5.12 and 3.83 in rats not treated with the hormone. The results are explained in terms of the greater stability of Sr than Ca with citrate, lactate, and other chelating metabolites, which promote the mobilization of bone mineral under the influence of parathyroid hormone. The cation-organic acid complex thus formed results in higher serum levels and lower renal excretion of Sr as compared with Ca ions. An effect similar to that shown with the hormone could be demonstrated in animals treated with fluoroacetate, which inhibits the catabolism of citrate. After 30 days on the Ca diet containing fluoroacetate, the Sr contents of compact and spongy bone were 20--30% higher than in the bone of rats not fed this metabolic inhibitor. (BBB)
- Research Organization:
- Universitat, Munich
- NSA Number:
- NSA-17-038709
- OSTI ID:
- 4645585
- Journal Information:
- Biochemische Zeitschrift (West Germany) Superseded by Eur. J. Biochem., Journal Name: Biochemische Zeitschrift (West Germany) Superseded by Eur. J. Biochem. Vol. Vol: 333; ISSN BIZEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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