The simultaneous identification of metoprolol and its major acidic and basic metabolites in human urine by gas chromatography-mass spectrometry
Journal Article
·
· Instrumentation Science and Technology
- Universite du Quebec, Pointe-Claire (Canada)
A novel gas chromatography-mass spectrometric (GC-MS) method was developed to confirm and identify metoprolol and its metabolites by double derivatization with S-(-)menthyl chloroformate [(-)-MCF] and N-methyl(trimethylsilyl-trifluoroacetamide) (MSTFA). This is the first report, which describes the simultaneous identification of metoprolol, its one major acidc and other basic metabolites in human urine based on solid-phase extraction with C{sub 18} reversed-phase cartridges. 12 refs., 4 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 458764
- Journal Information:
- Instrumentation Science and Technology, Journal Name: Instrumentation Science and Technology Journal Issue: 1 Vol. 24; ISSN ISCTEF
- Country of Publication:
- United States
- Language:
- English
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