Extraction of Sulfur Mustard Metabolites from Urine Samples and Analysis by Liquid Chromatography-High-Resolution Mass Spectrometry (LC-HRMS)
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
The following procedure describes the extraction of sulfur mustard metabolites (principally 1,1’-sulfonylbis[2-(methylthio)ethane] (SBMTE)) and related chemicals from urine and subsequent analysis by liquid chromatography with detection by high resolution mass spectrometry (LC-HRMS) to determine signatures present in a contaminated urine sample. Positive identification of such signatures in urine may signify patient exposure to sulfur mustard (HD). A future SOP will detail analysis of these metabolites by gas chromatography-tandem mass spectrometry (GC-MS/MS).
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE National Nuclear Security Administration (NNSA)
- DOE Contract Number:
- AC52-07NA27344
- OSTI ID:
- 1165796
- Report Number(s):
- LLNL--TR-659681
- Country of Publication:
- United States
- Language:
- English
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