RBE of neutrons in vivo

Conference · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4389538

Karen, K F; Phillips, T L; Rowe, J R

From American Society of Therapeutic Radiologists meeting; New Orleans, Louisiana, USA (25 Oct 1973). The potential for neutrons in radiation therapy depends on a differential in RBE for tumor versus normal tissues. To study this the responses of normal and tumor tissues to 15-MeV and /sup 252/Cf neutrons were compared with responses to /sup 137/Cs gamma or 300 KVP x rays in the mouse in vivo. Using 1% survival as a biological end point, the RBE's of 15-MeV and /sup 252/Cf neutrons are 2.29 and 5.13 (/sup 137/Cs at 4.5 rads/min) respectively for the EMT6 tumor and 1.48 and 2.45 (/sup 137/Cs at 4.5 rads/min) respectively for bone marrow CFU's. For pulmonary and esophageal lethality, the RBE values of 15- MeV neutrons are 2.24 and 4.08. With 15-MeV neutrons, the RBE for the tumor is greater than the bone marrow CFU. The RBE for pulmonary lethality is less than that for esophageal lethality. With /sup 252/Cf, the RBE tor the EMT6 tumor, although greater than the bone marrow CFU, is not significantly different from reported in vivo RBE values of normal tissues at comparable gamma dose rates. (auth)

• Research Organization: California Univ., San Francisco (USA)
• NSA Number: NSA-29-005331
• OSTI ID: 4389538
• Report Number(s): UCSF--10-P-2-213; CONF-731040--1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*NEOPLASMS-- BIOLOGICAL RADIATION EFFECTS
*NEUTRONS-- RBE
*TISSUES-- BIOLOGICAL RADIATION EFFECTS
BONE MARROW
CALIFORNIUM 252
CESIUM 137
GAMMA RADIATION
LUNGS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
RADIATION SOURCES
RADIOTHERAPY
X RADIATION