Effect of autonomic nerve stimulants on the distribution of /sup 99m/Tc- pertechnetate

Journal Article · Fri Dec 31 23:00:00 EST 1971 · Kanazawa Irigaku Sosho, v. 91, pp. 51-68

OSTI ID:4383458

Nakamura, J

This study was performed in anticipation of an improvement of radioisotopic examination with /sup 99m/Tc-pertechnetate and of changing organ accumulation of /sup 99m/Tc-pentechnetate with administration of autonomic nerve stimulants. Changes of organ accumulation of /sup 99m/Tc-pertechnetate were followed at 15, 30, 60, 120, 180, and 300 min after administration of autonomic nerve stimulants. Using rats, the accumulation of /sup 99m/Tc-pertechnetate in the thyroid gland, parotid gland, sudmandibular gland, brain, liver, spleen, kidney, and blood were determined. An organ of highest accumulation of /sup 99m/ Tc-pertechnetate was the thyroid gland. Continuously, in the liver, kidney, parotid gland, submandibular gland, spleen, and brain, the accumulation became low and the accumulation in the blood was relatively high. In control group, the all organ accumulation of /sup 99m/Tc-pertechnetate were highest at 30 min after injection into abdominal cavity and after 120 min gradually decreased. In the group administered noradrenalin (sympathetic nerve stimulant) at 15 min before injection of /sup 99m/Tc-pertechnetate, the accumulation of the thyroid gland, brain, liver, and kidney decreased early. In the group of administered noradrenalin at 15 min before sacrificing rat, the uptake of only the brain decreased early. In the group administered vagostigmin (parasympathetic nerve stimulant) at 15 min before injection of /sup 99m/Tc-pertechnetate, accumulation of the submandibular gland, parotid gland, and kidney decreased. In contrast with these, the accumulation in the liver rose. Also in the group administered vagostigmin at 15 min before sacrificing rat, a high accumulation in the liver was also revealed and kept for relative long period. (auth)

• Research Organization: Kanazawa Univ., Japan
• NSA Number: NSA-29-008097
• OSTI ID: 4383458
• Journal Information: Kanazawa Irigaku Sosho, v. 91, pp. 51-68, Journal Name: Kanazawa Irigaku Sosho, v. 91, pp. 51-68; ISSN KISOA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*NORADRENALINE-- BIOLOGICAL EFFECTS
*PARASYMPATHOMIMETICS-- BIOLOGICAL EFFECTS
*RATS-- RADIONUCLIDE KINETICS
*TECHNETIUM 99-- TISSUE DISTRIBUTION
BIOLOGICAL HOT SPOTS
BLOOD
BRAIN
KIDNEYS
LIVER
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
N48830 --Life Sciences--New Tracer Techniques--Other
PERTECHNETATES
SALIVARY GLANDS
SPLEEN
THYROID
TIME DEPENDENCE