Modification of radiation hazards to the adult and its fetus from nuclear medicine procedures

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:4065579

Lathrop, K A

The effects of perchlorate on the quantitative distribution patterns of / sup 99m/Tc intravenously administered as pertechnetate in the human adult and its fetus were studied in a variety of situations and are summarized. Perchlorate, when administered shortly before /sup 99m/Tc, suppresses concentration in the adult thyroid gland, stomach, and urine; but tends to increase intestinal localization; and prolongs disappearance from the blood. It also inhibits concentration in the placenta and fetus. The greatest reductions in fetal concentrations occur in the femur, spleen, stomach, and thyroid. The estimated radiation absorbed doses to the human fetus are about 80 mrad/mCi for /sup 99m/Tc- pertechnetate alone, and around 30 mrad/mCi if pretreatment with perchlorate is used. Previously localized /sup 99m/Tc may be released by perchlorate from the thyroid gland and stomach, but not from the placenta and fetus. (auth)

• Research Organization: Chicago Univ., Ill. (USA). Dept. of Radiology; Franklin McLean Memorial Research Inst., Chicago, Ill. (USA)
• NSA Number: NSA-33-023610
• OSTI ID: 4065579
• Report Number(s): CONF-760202--33
• Country of Publication: United States
• Language: English

Related Subjects

*FETUSES-- RADIONUCLIDE KINETICS
*TECHNETIUM 99-- TISSUE DISTRIBUTION
*WOMEN-- RADIONUCLIDE KINETICS
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
BIOLOGICAL EFFECTS
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
N48710 --Life Sciences--Nuclide Kinetics & Toxicology--Man
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
PATIENTS
PERCHLORATES
PERTECHNETATES
RADIATION DOSES
RADIATION HAZARDS
RADIONUCLIDE ADMINISTRATION
RADIOPHARMACEUTICALS