Origin and location of the oral activity in sequential salivary gland scintigraphy with /sup 99m/Tc-pertechnetate

Journal Article · Mon Nov 01 04:00:00 EST 1976 · J. Nucl. Med.; (United States)

OSTI ID:7332386

van den Akker, H P; Sokole, E B; van der Schoot, J B

Conflicting views exist regarding the origin and location of the oral radioactivity seen in salivary gland scintigraphy with /sup 99m/Tc-pertechnetate. The normal accumulation of oral activity was studied in a series of healthy subjects by sequential scintigraphy (anterior and lateral views) after intravenous injection of 2 mCi of /sup 99m/Tc-pertechnetate. Ligation of the parotid ducts and/or cannulation of the submandibular ducts, which prevented their secretions from reaching the oral cavity, established that the oral activity was due entirely to radioactive saliva secreted by the parotid and submandibular glands. Pertechnetate mouthwash studies confirmed that radioactive saliva is adsorbed to oral mucosa and that adsorption to the lingual mucosa is the major contributor to the oral activity. Pertechnetate uptake in sublingual and minor salivary glands of the oral cavity was not visualized, thereby invalidating scintigraphy in the study of these glands. In the diagnosis of salivary gland disorders, oral activity is a useful indicator of major salivary gland function.

• Research Organization: Univ., Amsterdam
• OSTI ID: 7332386
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORAL CAVITY
ORGANS
RADIOACTIVITY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SALIVA
SALIVARY GLANDS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES