EXPERIMENTAL PROBLEMS OF CHEMICAL RADIO-PROTECTION (in French)
Journal Article
·
· Journal Belge de Radiologie (Belgium)
OSTI ID:4334975
The possible radioprotective action of numerous substances (cyanide- group, amino-group, and lastly cysteamine and cystamine) has been studied by the method of >. A reproducible quantitative estimation of the protective action on limlted animal series is thus obtained. Several of these substances were found to give a positive protective action against radiation which was remarkable in the case of cysteamine and cystamine. The peritoneal injection of cysteamine and cystamine increases the survival percentage of irradiated animals and cystamine is also effective when given by mouth. The protective action of cysteamine given by intraperitoneal injection and cystamine, given by mouth, was studied by analysis of probits in special conditions, namely, total irradiation by gamma radiations. The results show that the lethal effect can be statistically assimilated to the joint and independent action of at least two components. It presents certain modalities of the complex mechanisms of death by radiation and of the specific action of the chemical protectors. Moreover, cystamine given by mouth, during a prolonged time (a month or more diminishes the radiotoxicity of injected P/sup 32/. The regression curves of the mortality probits studied, give useful precisions on the D.R.F. (dosereduction factor). The D.R.F. of cysteamine and cystamine varies with the dose and these changes can be estimated from the regression-coefficients. Cysteamine and cystamine have a local protective action after segmental irradiation. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-12-007687
- OSTI ID:
- 4334975
- Journal Information:
- Journal Belge de Radiologie (Belgium), Journal Name: Journal Belge de Radiologie (Belgium) Vol. Vol: 41; ISSN JBRAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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· Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals
·
OSTI ID:4654543