Influence of the Amount of Irradiation on the Incidence of Radio-Leukemia; INFLUENCE DES MODALITES D'IRRADIATION SUR L'INCIDENCE DES RADIO- LEUCEMIES
Technical Report
·
OSTI ID:4266162
The effects of some circumstances of fractionation and protraction on the incidence of lymphosarcomas in mice exposed to different doses of gamma radiation were studied. The effect of chemical protection with cysteamine or cystamine on these factors was also investigated. In two series of experiments the animals received 301, 406, 550, or 742 r in two fractions five days apart. In the first series the animals were given an intraperitoneal injection of cysteamine or cystemine before each irradiation. In the second series the animals received cysteamine orally. In a third series the animals received a total dose of 640 r in four fractions at intervals of seven days with an intraperitoneal injection of cysteamine before each irradiation. In the fourth series the animals were treated as in the third series, but they also received streptomycin in the drinking water. The number of tumors in the animals surviving the irradiation was determined. The results are tabulated. The incidence of tumors increases with the total irradiation dose received. At equal doses, the carcinogenic effect of a fractionated irradiation is greater than that of a single dose. The chemical protection does not modify the carcinogenic effect of radiation in the same manner as its lethal effect. Cysteamine and cystamine are not carcinogenic agents. (J.S.R.)
- Research Organization:
- Oak Ridge Inst. of Nuclear Studies, Inc., Tenn.; Univ. of Liege
- NSA Number:
- NSA-13-006246
- OSTI ID:
- 4266162
- Report Number(s):
- A/CONF.15/P/1696
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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