Radiosensitivity of Ehrlich ascites tumor cells in different growth phases and its enhancement by iodoacetamide

Journal Article · Sat Sep 01 04:00:00 EDT 1973 · J. Radiat. Res., v. 14, no. 3, pp. 236-247

OSTI ID:4331530

Tanaka, N

The x-ray survival curve of Ehrlich ascites tumor cells and its modification by iodoacetamide were determined by the TD/sub 50/ assay. Survival curves for tumor cells of 1-, 6-, and 12-days after transplantation were examined in the presence or in the absence of the agent. The D/sub O/ was 130, 350, or 230 rads for 1-, 6-, and 12-day-old tumor cells, respectively. The response to x- rays of 1- and 6day-old tumor cells was enhanced by iodoacetamide, while that of 12-day-old or stationary phase tumor cells was hardly enhanced. The increased radiosensitivity and the lowered sensitization by iodoacetamids of 12-day-old tumor cells might be attributed to an incressed proportion of the stationary phase cells. (auth)

• Research Organization: Kyoto Prefectural Univ. of Medicine
• NSA Number: NSA-29-024499
• OSTI ID: 4331530
• Journal Information: J. Radiat. Res., v. 14, no. 3, pp. 236-247, Journal Name: J. Radiat. Res., v. 14, no. 3, pp. 236-247; ISSN JRARA
• Country of Publication: Japan
• Language: English

Related Subjects

*AMIDES-- RADIOSENSITIVITY EFFECTS
*ASCITES TUMOR CELLS-- RADIOSENSITIVITY
*ORGANIC IODINE COMPOUNDS-- RADIOSENSITIVITY EFFECTS
DOSE- RESPONSE RELATIONSHIPS
EHRLICH ASCITES TUMOR
GROWTH
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIOSENSITIZERS
SURVIVAL CURVES
TIME DEPENDENCE
WHOLE-BODY IRRADIATION
X RADIATION