Effects of iodoacetamide and x rays on a murine ascites tumor
Journal Article
·
· Radiat. Res.; (United States)
The radiosensitizing properties of iodoacetamide (IA) have been studied using as end point the proliferative capacity of an ascites tumor (lymphoma, LSA) of the C57BL mouse. When the cells were irradiated in vitro, TD/sub 50/ assays gave a survival curve with D/sub 0/ = 120 +- 20 rad and n = 4.0. When cells were irradiated in the presence of 10/sup -3/M iodoacetamide (IA), the shoulder of the curve was eliminated, but the slope was not changed. In vivo-in vivo experiments were performed using a 7-day-old tumor. The cells were treated in the donor mice, which were injected ip with 10/sup 4/ cells 7 days before treatment. Survival curves for x rays alone gave D/sub 0/ = 369 +- 50 rad, with n = 1.70. Irradiation after injection of 0.37 mg of IA eliminated the shoulder and changed the slope (D/sub 0/ = 243 +- 35 rad). The ratio of the D/sub 0/'s gave a slope ratio of 1.52 +- 0.32, indicating a sensitizing action of the iodoacetamide. Using the potentiating factor (PF), defined as the ratio of the expected to the experimental surviving fraction of the combination, an average PF = 5.61 was obtained. PFs significantly greater than 1.0 indicate a synergistic effect of IA and x rays.
- Research Organization:
- Univ. of Minnesota, Minneapolis
- OSTI ID:
- 7256457
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 70:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETAMIDE
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
DISEASES
EHRLICH ASCITES TUMOR
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
HALOGEN COMPOUNDS
IODINE COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETAMIDE
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
DISEASES
EHRLICH ASCITES TUMOR
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
HALOGEN COMPOUNDS
IODINE COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION