Damage of rat thyroid by $sup 131$I and evidence against immunologic transferability

Journal Article · Fri Feb 01 04:00:00 UTC 1974 · Radiat. Res., v. 57, no. 2, pp. 288-299

OSTI ID:4331321

White, S C; Casarett, G W

Young adult male rats given single injections of /sup 131/I (100, 300, or 500 mu Ci) or multiple injections of /sup 131/I (33 or 167 mu Ci weekly for 3 weeks) were studied periodically for up to 8 weeks for thyroid histopathology and evidence of immunologic transferability of radiation-induced thyroid lesions. The single injections of 300 or 500 mu Ci initiated an early acute inflammatory response in the thyroid gland. By 8 weeks extensive parenchymal degeneration was evident. After the dose of 100 mu Ci /sup 131/I an effect was seen at 8 weeks when a mild diffuse degeneration was evident. Fractionation of the 500- mu Ci injection (into three weekly injections of 167 mu Ci) resulted in only moderate parenchymal degeneration and more uniform destruction of thyroid tissue. Passive transfer of serum and/or lymphoid cells from nail-treated donors to nontreated young adult male rats failed to demonstrate transferability of the lesion. (auth)

• Research Organization: Univ. of Rochester, NY
• NSA Number: NSA-29-024520
• OSTI ID: 4331321
• Journal Information: Radiat. Res., v. 57, no. 2, pp. 288-299, Journal Name: Radiat. Res., v. 57, no. 2, pp. 288-299; ISSN RAREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*IODINE 131-- BIOLOGICAL RADIATION EFFECTS
*THYROID-- IMMUNE REACTIONS
BLOOD SERUM
DOSE-RESPONSE RELATIONSHIPS
INFLAMMATION
INTRAPERITONEAL INJECTION
LYMPHOCYTES
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
PATHOLOGY
RADIONUCLIDE KINETICS
RATS