Response of Chinese hamster (ovary) cells to protracted irradiation from $sup 252$Cf and $sup 60$Co
Journal Article
·
· Brit. J. Radiol., v. 46, no. 551, pp. 991-995
OSTI ID:4328097
Chinese hamster (ovary) cells were exposed to the protracted irradiation of /sup 252/Cf or /sup 60/Co under conditions of aeration or extr eme hypoxia. Dose response curves were computed and these indicated values for oxygen enhancement ratio (OER) of 1.42 for /sup 60/Co irradiation at 100 rads/hr and 2.18 for /sup 252/Cf irradiation at a mean doserate of 15 rads/hr. From these values the therapeutic gain factor (TGF) would be only 0.65. Values for relative biological effectiveness (RBE) would be 6.7 for aerated cells and 4.4 for hypoxic cells. It is suggested from these data that no advantage would be gained by substituting /sup 252/Cf orthodox gamma sources in interstitial radiotherapy. (auth)
- Research Organization:
- Christie Hospital and Holt Radium Inst., Manchester, Eng.
- NSA Number:
- NSA-29-026973
- OSTI ID:
- 4328097
- Journal Information:
- Brit. J. Radiol., v. 46, no. 551, pp. 991-995, Journal Name: Brit. J. Radiol., v. 46, no. 551, pp. 991-995; ISSN BJRAA
- Country of Publication:
- United Kingdom
- Language:
- English
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Related Subjects
*ANIMAL CELLS-- BIOLOGICAL RADIATION EFFECTS
*GAMMA RADIATION-- RBE
*OXYGEN-- RADIOSENSITIVITY EFFECTS
*RADIOTHERAPY-- GAMMA RADIATION
ANOXIA
CALIFORNIUM 252
CHRONIC IRRADIATION
COBALT 60
COMPARATIVE EVALUATIONS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
FISSION NEUTRONS
HAMSTERS
IN VITRO
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
NEUTRON BEAMS
OVARIES
OXYGEN ENHANCEMENT RATIO
PHOTON BEAMS
RADIATION SOURCE IMPLANTS
RESPONSE MODIFYING FACTORS
*GAMMA RADIATION-- RBE
*OXYGEN-- RADIOSENSITIVITY EFFECTS
*RADIOTHERAPY-- GAMMA RADIATION
ANOXIA
CALIFORNIUM 252
CHRONIC IRRADIATION
COBALT 60
COMPARATIVE EVALUATIONS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
FISSION NEUTRONS
HAMSTERS
IN VITRO
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
NEUTRON BEAMS
OVARIES
OXYGEN ENHANCEMENT RATIO
PHOTON BEAMS
RADIATION SOURCE IMPLANTS
RESPONSE MODIFYING FACTORS