Biological effects of Cf-252 gamma-neutron radiation: A summary of studies in the USSR

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6705606

Konoplyannikov, A G; Vtyurin, B M

Studies of the radiobiology of /sup 252/Cf radiation were carried out to evaluate the biological effects of /sup 252/Cf radiation for mouse skin irradiated at low dose rates of 0.21 - 0.62 Gy/hr. RBE's were 5.2 - 7.5 compared to equivalent doses of /sup 60/Co gamma rays. For rats RBE values were 5.6 - 5.8 for erythema and 5.9 for moist reaction and epilation. High dose rate /sup 252/Cf irradiation of --0.3 - 0.7 Gy/min led to a decrease in RBE of about 2 - fold for a variety of endpoints. Under hypoxic conditions RBE was determined for Drosophila spermatid damage and RBE was found higher for hypoxic spermatids. Human hemopoietic cells had low RBE values of 1.2 - 1.5. Cytogenetic studies of chromosomes revealed that the neutron components produced the dominant effects observed and RBE's varied from 1.7 - 2.7 relative to /sup 60/Co. When studied at a dose rate of 0.0035 Gy/min RBE was 6.0. Studies of tumor bed effect for /sup 252/Cf suggest that bed effects can affect rumor response and late effects.

• Research Organization: Research Institute of Medical Radiology of Academy of Medical Science of USSR, Obninsk
• OSTI ID: 6705606
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
ARTHROPODS
ASIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DIPTERA
DISEASES
DOSE RATES
DROSOPHILA
EASTERN EUROPE
ELECTROMAGNETIC RADIATION
EMISSION
ERYTHEMA
EUROPE
EVEN-EVEN NUCLEI
FLIES
FRUIT FLIES
GAMMA RADIATION
HEAVY NUCLEI
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUTRON EMISSION
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PHOTON EMISSION
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RATS
RBE
RESEARCH PROGRAMS
RODENTS
SKIN
SYMPTOMS
THERAPEUTIC USES
THERAPY
USES
USSR
VERTEBRATES
YEARS LIVING RADIOISOTOPES