Survival of murine leukaemia cells exposed to $sup 252$Cf neutrons under conditions simulating implantation of these sources into tissue in radiotherapy

Journal Article · Thu Nov 01 04:00:00 EST 1973 · Brit. J. Radiol., v. 46, no. 551, pp. 996-1004

OSTI ID:4307319

Berry, R J; Oliver, Jr, G D; George, D L; Werner, J; Brennan, J T

Murine P-388 leukemia cells were irradiated with either radium gamma rays, or the mixed fast neutron and gamma emission from /sup 252/Cf, in a geometrical set-up simulating the use of such. sources in brachyradiotherapy. Survival of reproductive capacity of the tumor cells was assayed in vivo. At the relatively high dose rates used (circa 240 to 280 rads/hr) the relative biological effectiveness (RBE) of the fast neutrons from /sup 252/Cf was 2.7 to 3.8 for irradiation under aerobic conditions and 3.3 to 5 for irradiation in nitrogen. The oxygen enhancement ratio (OER) was 2.3 for irradiation with radium gamma rays and 1.9 for irradiation with /sup 252/Cf, a potential therapeutic gain factor (TGF) circa 1.2 for the use of these sources in treatment of tumors containing significant proportions of hypoxic cells. (auth)

• Research Organization: Churchill Hospital, Oxford
• NSA Number: NSA-29-024488
• OSTI ID: 4307319
• Journal Information: Brit. J. Radiol., v. 46, no. 551, pp. 996-1004, Journal Name: Brit. J. Radiol., v. 46, no. 551, pp. 996-1004; ISSN BJRAA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*CALIFORNIUM 252-- RBE
*FAST NEUTRONS-- OXYGEN ENHANCEMENT RATIO
*GAMMA RADIATION-- OXYGEN ENHANCEMENT RATIO
*RADIOTHERAPY-- RADIATION SOURCE IMPLANTS
*TUMOR CELLS-- SURVIVAL CURVES
ANOXIA
COMPARATIVE EVALUATIONS
DOSE RATES
LEUKEMIA
MICE
N48210 --Life Sciences--Radiation Effects on Cells--External Source
N48510* --Life Sciences--Radiation Effects on Animals--Man
NEUTRON BEAMS
PHOTON BEAMS
RADIUM
RESPONSE MODIFYING FACTORS
SIMULATION
TISSUES