Change of oxyproline-containing compounds in plasma and urine after irradiation

Journal Article · Fri Mar 01 04:00:00 EDT 1974 · Med. Radiol., v. 19, no. 3, pp. 51-56

OSTI ID:4324298

Nesterova, V I; Davydova, S A; Poluboyarinova, Z I; Vodyakova, L M

The authors studied the changes of protein-bound oxyproline level in the plasma and total oxyproline of the urine in acute radiation sickness in mice (dose of gamma irradiation is 800 and 950 R) with local BETA irradiation (dose---5000 rad). In cases of acute radiation sickness the authors found the increase of oxyproline excretion on the 4th and 5th days after irradiation. In burns due to BETA -irradiation the increase of excretion was observed earlier (the second day) and was followed by a considerable lowering of the oxyproline level in the urine during the period of erosiveulcerous affection of the skin. The revcaled changes can testify to the increase of collagen catabolism in radiation injury of the tissue in a relatively early period with further inhibition of the synthetic reparative processes. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-29-029831
• OSTI ID: 4324298
• Journal Information: Med. Radiol., v. 19, no. 3, pp. 51-56, Journal Name: Med. Radiol., v. 19, no. 3, pp. 51-56; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

*AMINO ACIDS-- BIOCHEMICAL REACTION KINETICS
*COLLAGEN-- CATABOLISM
*RADIATION SYNDROME-- BIOCHEMICAL REACTION KINETICS
BETA PARTICLES
BIOLOGICAL RADIATION EFFECTS
BLOOD PLASMA
GAMMA RADIATION
IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
QUANTITY RATIO
URINE