CREATINURIA IN PREGNANT AND NON-PREGNANT RATS AFTER EXPOSURE TO PENETRATING RADIATION

Journal Article · Tue Jan 01 04:00:00 EST 1957 · Trudy Vsesoyuz. Konf. Med. Radiol.

OSTI ID:4132288

Zhakhova, Z N; Braun, A D

Disturbance of the creatine-creatinine balance in radiation sickness is an indication of general dystrophy. The normal excretion of creatine in the urine of healthy rats is 0.7 mg per day and that of creatinine is 4.6 mg per day. A fivefold increase in the amount of creatine excreted was observed on the second day after administration of a dose of 500 r with a return to normal levels on the 5th to 6th day after irradiation. The severity of the creatinuria is significantly higher for pregnant rats irradiated just before childbirth than it is for pregnant rats irradiated on the 1lth to 12th day of pregnancy or for nonpregnant irradiated rats. The clinical symptoms of radiation sickness in the group of rats irradiated on the 11th to 12th day of pregnancy were much less pronounced. but the fetus died and was readsorbed. Irradiation of rats on the 19th day of pregnancy results in a prolongation of the gestation period to 24 to 25 days instead of a normal period of 21 to 22 days. The determination of the content of creatine and of creatinine can serve as a diagnostic aid in radiation sickness. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-002510
• OSTI ID: 4132288
• Journal Information: Trudy Vsesoyuz. Konf. Med. Radiol., Journal Name: Trudy Vsesoyuz. Konf. Med. Radiol.
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
FETUSES
METABOLISM
PREGNANCY
RADIATION EFFECTS
RADIATION SICKNESS
RATS
REPRODUCTION
URINE