Changes in aminotransferase and aldolase activity in blood serum of dogs exposed to chronic and combined gamma radiation for 6 years

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5388625

Akhunov, A A

Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and aldolase (ALD) activity of blood serum in the course of chronic exposure to radiation for 6 years and following additional acute irradiation was studied. Dogs were exposed to chronic ..gamma.. radiation from /sup 60/Co sources for 22 h daily, at the rate of 0.06 rad/day (1st group), 0.17 rad/day (2d, 4th and 5th groups) and 0.34 rad/day (3d group). Against the background of chronic exposure, the 4th group was additionally exposed to acute radiation in doses of 8 rad x 2 and 42 rad x 1, and the 5th group, in doses of 42 rad x 3, at 4-month intervals. Some of the animals exposed to radiation for 6 years in the same doses as the 4th and 5th groups, as well as previously nonirradiated (control) animals were submitted to test radiation in a dosage of 125 rad from a /sup 137/Cs source, at a dose rate of 10 rad/min. The studies demonstrated changes in activity of aminotransferases and aldolases of blood serum, both in the case of chronic exposure of dogs to ..gamma.. radiation and a combination thereof with acute irradiation. However, the demonstrated dynamic changes in blood serum enzyme activity were transient and unstable. Evidently, the reversible nature of changes in enzyme activity is related to initiation of compensatory processes. (ERB)

• Research Organization: Inst. of Biomedical Problems, Moscow, USSR
• OSTI ID: 5388625
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:3; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ALDOLASES
ALKALI METAL ISOTOPES
AMINOTRANSFERASES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
CESIUM 137
CESIUM ISOTOPES
CHRONIC EXPOSURE
CHRONIC IRRADIATION
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DOGS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYASES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
TRANSFERASES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES