QUARTERLY PROGRESS REPORT NO. 27

Technical Report · Tue Apr 15 04:00:00 EST 1958

OSTI ID:4315162

A new group of 2-aminoethylisothiourea (AET) derivatives were synthesized for biological screening in an effort to discover related substances with greater radiation protective activity than AET. Fifty-three chemical compounds were tested for protective activity against mortality and weight loss in mice exposed to lethal doses of x radiation. Nineteen of the compounds exhibited significant radioprotective effects. The most marked protective effects were obtained following the pre-radiation administration of 2- aminopropylisothiuronium sulfate. Measurements were made on the mortality, body weight, and ocular changes during the first year following chronic exposure of mice to low doses of gamma and fast neutron irradiation. Data are presented from a study on the effects of AET on carbohydrate metabolism in rats and other mammalian species, and the effects of the compound on purified sulfhydryl enzymes. (For preceding period see NP-6639.) (C.H.)

• Research Organization: Chicago. Univ. Air Force Radiation Lab.
• NSA Number: NSA-12-015281
• OSTI ID: 4315162
• Report Number(s): NP-6734
• Country of Publication: United States
• Language: English

Related Subjects

AET-- ANIMALS-- CARBOHYDRATES-- ENZYMES-- IMPURITIES-- MAMMALS-- METABOLISM-- ORGANIC NITROGEN COMPOUNDS-- ORGANIC SULFUR COMPOUNDS-- RATS-- VARIATIONS
AET-- BODY-- CHEMICALS-- EFFICIENCY-- EYES-- GAMMA RADIATION-- LETHAL DOSE-- MICE-- ORGANIC NITROGEN COMPOUNDS-- ORGANIC SULFUR COMPOUNDS-- RADIATION EFFECTS-- RADIATION PROTECTION-- RADIOSENSITIVITY-- SURVIVAL TIME-- TESTING-- TISSUES-- VARIATIONS-- WEIGHT-- X RADIATION
BIOLOGY AND MEDICINE