QUARTERLY PROGRESS REPORT NO. 31

Technical Report · Wed Apr 15 04:00:00 EST 1959

OSTI ID:4267937

Results are reported from a study of the survival time and mortality of mice treated with fifty-five chemical ccmpounds immediately prior to the administration of a lethal dose of whole-body x rad.ation. Of the compounds tested only two, ethoxymethylene malonitrile and HA-2, exhibited significant radioprotective activity. Chemical formulas for the conipounds are included. Results are presented from studies on the survival time, weight loss, and mortality of mice treated with adrenosem salicylate immediately prior to the administration of a lethal dose of whole-body x radiation. The effect of the adrenosem treatment on the tissue respiration of normal and x irradiated mice was also studied. Data are included from studies on the kinetic and synthetic aspects of the acidcatalyzed reactions of cyclic imines with thiourea and its analogs. Mortality patterns were established for LAF, male mice following exposure to low level fractionated gamma and fast neutron irradiation. The incidence and rate of progression of lens opacities and iris atrophy were also determined for male LAF mice following exposure to fractionated low level gamma and fast neutron irradiation. Mortality patterns were also determined for mice following various patterns of exposure to x radiation. Data are included from a study of the protective effect of various chemical agents against radiation damage in speeific adiosensitive tissues. Determinations were made of their ability to modify the radiation-induced changes in enzyme activities. Preliminary experiments are described on the effects of radioprotective drugs and whole-body x radiation on the reduced glutathione (GSH) concentrations in the tissues of rats and mice. A protective effect was demonstrated for GSH against AET toxicity in rats and mice. (For preceding period see NP-7301.) (C.H.)

• Research Organization: Chicago. Univ. Air Force Radiation Lab.
• NSA Number: NSA-13-013147
• OSTI ID: 4267937
• Report Number(s): NP-7527
• Country of Publication: United States
• Language: English

Related Subjects

ACIDS-- ALKENES-- BODY-- CATALYSIS-- COMPOUNDS-- CYANIDES-- EFFICIENCY-- ETHOXY RADICALS-- IMINES-- LETHAL DOSE-- MALIC ACID-- METHYLENE-- MICE-- MORTALITY-- NITRILES-- ORGANIC ACIDS-- ORGANIC COMPOUNDS-- ORGANIC NITROGEN COMPOUNDS-- ORGANIC SULFUR COMPOUNDS-- OXIDATION-- RADIATION PROTECTION-- REACTION KINETICS-- SURVIVAL TIME-- TESTING-- TISSUES-- UREA-- VARIATIONS-- WEIGHT-- X RADIATION
AET-- AGE-- AMINO ACIDS-- BODY-- CHEMICALS-- DRUGS-- EFFICIENCY-- ENZYMES-- EYES-- FAST NEUTRONS-- GAMMA RADIATION-- GLUTATHION-- LENSES-- MICE-- ORGANIC SULFUR COMPOUNDS-- RADIATION DOSES-- RADIATION EFFECTS-- RADIATION PROTECTION-- RADIOSENSITIVITY-- SUR
BIOLOGY AND MEDICINE