QUARTERLY PROGRESS REPORT NO. 29

Technical Report · Wed Oct 15 04:00:00 EDT 1958

OSTI ID:4308533

An attempt was made to correlate the radioprotective activity of certain thiourea derivntives with their abillty to inhibit sulfhydryl enzyme systems of animal tissue s. Data are tabulated. Results suggest that reactions between radioprotective compounds and biological sulfhydryl groups are important in protecting animals against lethal doses of ionizing radintion. Lethal doses of x radiation failed to inhibit the cytochrome C and glutamine synthetase activity of several rat tissues. Studies were continued on the effect of x irradiation on the synthesis of citric acid by rnt tissues in vitro. Results provide additional information concerning the effects of x radiation on the irtermediary carbohydrate metabolism of animal tissues. Mortality dnta are included on mice 18 to 26 months after initial exposure to gamma and fast neutron irradiation. Preliminary measurements are reported on light reflectance from mouse fur following chronic exposure to low levels of fast neutrons. A reflectometer adapted for making the meas urements is described and illustrated with a schemntic sketch. Fifty-one chemical compounds were tested for their effects on survival time, weight loss, and mortality in mice exposed to doses of 800-r x radintion. Data are tabulated and presented graphically. Procedures are described for the synthesis of a number of 2aminoethylisothiuroninm analogs. The compounds will be tested as protective or therapeutic agents against radintion injury in experimental animals. (For preceding period see NP-6899.) (C.H.)

• Research Organization: Chicago. Univ. Air Force Radiation Lab.
• NSA Number: NSA-13-003519
• OSTI ID: 4308533
• Report Number(s): NP-7018
• Country of Publication: United States
• Language: English

Related Subjects

ACTIVATION-- AET-- ANIMALS-- BISMUTH-- EFFICIENCY-- ELEMENTARY PARTICLES-- EMISSION-- ENERGY RANGE-- GAMMA RADIATION-- IRRADIATION-- ORGANIC SULFUR COMPOUNDS-- PREPARATION-- RADIATION PROTECTION-- TESTING-- THERAPY
ACTIVATION-- ANIMALS-- BIOCHEMISTRY-- BISMUTH-- EFFICIENCY-- ELEMENTARY PARTICLES-- EMISSION-- ENERGY RANGE-- ENZYMES-- GAMMA RADIATION-- IRRADIATION-- LETHAL DOSE-- ORGANIC SULFUR COMPOUNDS-- RADIATION PROTECTION-- TISSUES-- UREA
ACTIVATION-- BIOCHEMISTRY-- BISMUTH-- CARBOHYDRATES-- CITRIC ACID-- ELEMENTARY PARTICLES-- EMISSION-- ENERGY RANGE-- GAMMA RADIATION-- IRRADIATION-- METABOLISM-- RADIATION EFFECTS-- RATS-- TISSUES-- X R
BIOLOGY AND MEDICINE